Predictors of responders to non-responders with DPP-IV inhibitor and association between oral antidiabetic use with hypoglycaemia and cardiovascular outcome
Supervisors: Dr Iskandar Idris & Professor Richard Donnelly
Applications are invited from highly motivated individuals for the above studentship, based at the School of Graduate Entry Medicine and Health at the Royal Derby Hospital.
Dipeptidyl peptidase IV (DPP-IV) inhibitor is a novel glucose lowering agent increasingly used in the United Kingdom for the management of hyperglycaemia in patients with type 2 diabetes. Evidence from clinical trials suggest that this class of drugs may offer advantage over other oral glucose lowering therapy due to reduced risks of hypoglycaemia and neutrality effect on patients body weight. Guidelines from the National Institute of Clinical Excellence (NICE) have recommended for DPP-IV inhibitor to be considered as a second or third line drug for patients with type 2 diabetes, particularly where there are concerns about patients risk of weight gain or hypoglycaemia.
